CASE STUDY

Ketamine Improves MDD and PTSD while Slowing Aging

‍Epigenetic aging and DNA methylation biomarker changes following ketamine treatment in patients with MDD and PTSD: a pilot study

COLLABORATING UNIVERSITIES

‍Expedition Mental Health; Wild Health, Inc.; Yale University School of Medicine

Summary Snapshot

‍Study Type: Pilot longitudinal interventional study

‍Sample Size: 20 participants (16 of whom completed the lab testing protocol)

‍Duration: 4 weeks

‍Primary Endpoint: Changes in epigenetic age acceleration and DNA methylation biomarkers (e.g., indicators of a trend toward slowed aging according to OMICmAge).

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The DNA Methylation Edge

The TruDiagnostic research team benefited from Epigenetic Biomarker Proxies (EBPs)' superior predictive capabilities, giving sharper clinical insights with less blood and in a shorter period of time. Used as an omic screening tool, EPBs in this study identified metabolic indicators of cellular damage, helping clinicians administer more precise and less potentially harmful doses of ketamine.

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The Takeaway

Ketamine infusions delivered over the course of two to three weeks can not only reduce symptoms of major depressive disorder (MDD) and posttraumatic stress disorder (PTSD), but also can affect biomarker indicators and epigenetic-driven aging.

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