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INTERVENTIONAL TRIALS
DNA Methylation
The Key to Smarter Interventional Trials
DNA methylation captures intervention effects at a systems level, delivering earlier, higher-resolution signal than traditional biomarkers across pharmacologic, nutritional, and behavioral studies.
DNA methylation captures intervention effects at a systems level, delivering earlier, higher-resolution signal than traditional biomarkers across pharmacologic, nutritional, and behavioral studies.
GLP-1s
Aging
Geroscience
Methylation Risk Scores
DNA Methylation
Mental Health
Immunity
Cellular Senescence
Epigenetic Biomarker Proxies
OUR TRIAL PARTNERS
120+ Interventional Trials with Pharma, Academic & Life Science Partners
Real-world examples of how our team will help advance your research.
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GLP-1s Slow Aging in People with HIV-associated Lipohypertrophy
University Hospitals Cleveland Medical Center; Case Western Reserve University; Yale University School of Medicine
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A Vegan Diet Slows Aging Faster than an Omnivorous Diet
Stanford University; Chan Zuckerberg Biohub; Seattle Children’s Research Institute; Weill Cornell Medicine
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Ketamine Improves MDD and PTSD while Slowing Aging
Expedition Mental Health; Wild Health, Inc.; Yale University School of Medicine
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The Effects of Psychedelics on Brain Function
Arizona State University; University of Southern California; Modern Spirit; Translational Genomics Research Institute (TGen)
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DNA Methylation Reveals Senolytic Treatments Do Not Reverse Epigenetic Aging
Yale University, Program in Computational Biology and Bioinformatics, Department of Pathology, Department of Psychiatry; Institute for Hormonal Balance
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OVER 80+ academic PARTNERSHIPS
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Why DNA Methylation Matters for Interventional Trials
Methylation patterns are powerful because they help reveal the interplay between genes, health behaviors, stressors, and more. TruDiagnostic’s tools highlight actionable epigenetic signals among the DNA noise. By tracking methylation changes over days or months, we capture the longitudinal impact of specific treatments and interventions to gauge effectiveness and reveal better targets for personalized therapy.
On its own, DNA hints at which diseases may develop and which areas of resilience a patient may possess, giving clues to how that person’s healthspan may unfold. In this way, DNA resembles a hard copy road map: good at showing the big picture, but static and missing crucial details.
Supplementing DNA with epigenetic methylation pattern recognition yields a much richer depiction of how a person’s genomic journey is progressing. By analyzing methylation and Epigenetic Biomarker Proxies (EBPs), researchers and clinicians can more clearly discern which genomic possibilities are becoming realities. This enables more targeted interventions and a better understanding of how to lower diseases and promote resiliency for each individual person.
On its own, DNA hints at which diseases may develop and which areas of resilience a patient may possess, giving clues to how that person’s healthspan may unfold. In this way, DNA resembles a hard copy road map: good at showing the big picture, but static and missing crucial details.
Supplementing DNA with epigenetic methylation pattern recognition yields a much richer depiction of how a person’s genomic journey is progressing. By analyzing methylation and Epigenetic Biomarker Proxies (EBPs), researchers and clinicians can more clearly discern which genomic possibilities are becoming realities. This enables more targeted interventions and a better understanding of how to lower diseases and promote resiliency for each individual person.
READY TO COLLABORATE?
How to Get the Most Out of DNA Methylation in Your Research
Methylation patterns are powerful because they help reveal the interplay between genes, health behaviors, stressors, and more. TruDiagnostic’s tools highlight actionable epigenetic signals among the DNA noise. By tracking methylation changes over days or months, we capture the longitudinal impact of specific treatments and interventions to gauge effectiveness and reveal better targets for personalized therapy.
Interventional research depends on statistical power and biological coverage. TruDiagnostic has built the world’s largest DNA methylation dataset, enabling partners to analyze intervention effects across diverse populations and contexts. Paired with purpose-built analytical software, this foundation supports faster signal detection, deeper stratification, and more confident conclusions.
DNA methylation captures biological change across multiple physiological systems. Partners can interrogate aging dynamics, treatment response, disease risk, and mechanism-level signals—supporting applications ranging from companion diagnostics and drug development to OMICs and bioinformatics research.
Our datasets are designed for reuse, not single-read outcomes. Researchers can examine intervention effects across time, re-analyze cohorts as new hypotheses emerge, and apply future biomarker frameworks without the need to recollect samples–maximizing the long-term value of each study.
We extend the value of methylation data through proprietary algorithms and epigenetic models that surface meaningful associations, reduce biological noise, and translate high-dimensional data into interpretable, trial-relevant insights.
OUR DNA METHYLATION TOOLS
Our research partners benefit from custom arrays and multi-clock algorithms to make real differences in real clients’ lives.
Explore core diagnostics, reporting tools, and research platforms trusted by leading clinicians and scientists.
Methylation Risk Scores (MRS)
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Epigenetic Biomarker Proxies (EBPs)
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Cellular Deconvolution
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Aging Clocks
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Companion Diagnostics
Do Interventions Change DNA Methylation?
Yes, epigenetic methylation patterns change as a result of their environment.
For example, well-designed interventions can remove undesirable methyl groups and free up binding sites in CpG islands, reactivating healthy gene expression; they can also promote positive methylation, helping prevent diseases and maintain healthy cellular functions.
Using appropriate arrays, bisulfite sequencing, biological clock models, and computational algorithms, our partner researchers can gain insights into the impact of various interventions with greater power and precision than ever before.
For example, well-designed interventions can remove undesirable methyl groups and free up binding sites in CpG islands, reactivating healthy gene expression; they can also promote positive methylation, helping prevent diseases and maintain healthy cellular functions.
Using appropriate arrays, bisulfite sequencing, biological clock models, and computational algorithms, our partner researchers can gain insights into the impact of various interventions with greater power and precision than ever before.
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Lifestyle Interventions
Even small shifts in health behaviors can have large impacts on the healthspan. Our habits like exercise and calorie restriction can reduce inflammation-linked hypermethylation, and stress management can prevent cortisol-induced change.
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Nutritional Interventions
What we eat can affect methylation by acting on metabolic pathways that affect signaling cascades. Diets rich in methyl donors, such as folate from greens, foster balanced, stable methylation, while polyphenols reduce hypermethylation.
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Pharmacological Interventions
DNA methyltransferase (DNMT) inhibitors like azacitidine demethylate directly silence genes during cancer therapy, while certain other inhibitors indirectly affect methylation via chromatin remodeling.
Procedural Interventions
Protocols such as hyperbaric chambers (oxygen therapy), saunas (heat and infrared exposures), exosome therapy, and stem cell therapies can materially affect methylation patterns.
Supercharge Your Next Interventional Trial With DNA Methylation
We depend on research partners as dedicated as you are to jointly expand our epigenetic knowledge base.
When you partner with us, you gain access not only to a database of epigenetic data from the largest DNAm database in the world – spanning more than 80,000 patients – but also the analytic tools and experts to make sense of it all.
TruDiagnostic lets you sift through genomic data with greater speed and precision and test your hypotheses more robustly. Because you are accessing an entire set of biological aging algorithms and not just a single model, your research studies are set up for success from the beginning. More specimens, more data, more experience, and more meaningful conclusions. It all adds up to better research and better overall care.
When you partner with us, you gain access not only to a database of epigenetic data from the largest DNAm database in the world – spanning more than 80,000 patients – but also the analytic tools and experts to make sense of it all.
TruDiagnostic lets you sift through genomic data with greater speed and precision and test your hypotheses more robustly. Because you are accessing an entire set of biological aging algorithms and not just a single model, your research studies are set up for success from the beginning. More specimens, more data, more experience, and more meaningful conclusions. It all adds up to better research and better overall care.
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